The Alleged Existence of Adrenalin (epinephrin) in Pathological Sera
نویسنده
چکیده
In a previous paper, 1 I concluded that no proof had hitherto been given that adrenalin is ever present in detectable amount in normal sera from the general circulation. I have since examined by similar methods a number of sera from clinical cases. In the first paper, the literature on the alleged detection of adrenalin in pathological sera and the so-called estimation of the variations in the adrenalin content of the blood in different diseases was sufficiently covered, and few further references will be given here. In describing my own results, I shall examine and illustrate by special experiments the difficulties in the methods hitherto employed which, in my opinion, render the search for adrenalin under any conditions in the general circulation quite unpromising and at present devoid of practical importance in clinical work. As will be shown, the methods used do suffice for the detection of adrenalin in serum obtained more or less directly from the adrenal glands when they are excited to activity. Accordingly, the failure of the methods in the case of the general mixed Mood is due, not to their inadequacy to detect adrenalin, but to the absence of that substance in the general circulation or to its presence in a concentration below the limit recognizable by the so-called biological tests. Since these tests, with the objects employed, depend solely on the interpretation of tracings, it is necessary to reproduce a considerable number of these and to refer to them in detail.
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 15 شماره
صفحات -
تاریخ انتشار 2003